Developed in collaboration with Mitchell Holland, Ph.D., Associate
Director of The Pennsylvania State University's Forensic Science Program. Review Dr. Holland's
GeneMarkerHID Poster.
Reduce analysis time by
up to 40% with GeneMarkerHID!
GeneMarker® HID is an excellent choice for all forensic profiling applications. This software can be employed as a "biologist friendly" replacement for GeneScan®/GenoTyper® or as an alternative to GeneMapper® ID. GeneMarker® HID uses advanced Windows® technology that is intuitive and easy to learn. In addition to standard STR analysis, GeneMarker HID has been optimized to analyze profiles from YSTRs, LCN samples, ABI's MiniFilerTM Kit, and Locus Specific Bracket (LSB) data. Relationship testing and databasing capabilities are essential for crime scene investigation, missing persons identification and paternity testing.
Kinship/Relationship/Pedigree Testing Module - Download University of North Texas Center for Human Identification Poster "The Relationship Testing Application of GeneMarkerHID," 19th Annual Symposium on Human Identity, October 2008, click here.
Relationship Testing Feature - Download University of North Texas Center for Human Identification Poster "The Relationship Testing Application of GeneMarkerHID," 19th Annual Symposium on Human Identity, October 2008, click here.
Advantages of GeneMarker HID are ease of use and accurate, quick analysis.
GeneMarker HID utilizes unique sizing algorithms and pattern recognition
technology to provide unparalleled accuracy up to 99%.
The majority of functions have been completely automated, using a “smart”
expert system software approach to eliminate the need for constant analyst intervention,
and to improve analysis to analysis consistency.
Often data pertinent to the case becomes available after the initial project analysis. In just three ‘clicks’ the new files are added and processed using the same parameters as the original project. This append feature provides accurate, consistent updates to projects.
Rapid Data
Processing, Instrument Correction and Compatibility
GeneMarker HID can perform STR analysis on over 1,000 lanes of data using
the following ABI
and Promega kits:
Identifiler®
SGM Plus®
PowerPlex®16
And Many More!
The software accepts data format out put by ABI PRISM® 310/3100/3130/3730
Genetic Analyzer instruments, as well as MegaBACE and Beckman CE systems.
GeneMarker HID automatically adjusts for— instrument spike, color
pull-up, peak pull-up, noisy data, saturated peaks, and stutter peaks—saving
significant analysis time and cost, efficiently analyzing raw STR data
within seconds. In addition, GeneMarker HID allows the user to conduct
a lane by lane overview of unprocessed raw data, permitting a quick quality
control assessment of your profiles.
Setting analysis parameters is accomplished through 3
easy-to-use dialogue boxes. Once parameters have been set, they can be
saved for future analysis, allowing “single click” operation
of the AutoRun feature.
A few notable features of GeneMarker HID’s analysis window include automatic RFU intensity ranging in the electropherogram, distinct peak flags, and several customizable viewing modes. In addition to a user friendly interface, GeneMarker HID also provides an enhanced quality scoring system that flags suspect alleles and identifies samples that have questionable size calling results.
Panel templates and size standards can either be selected from several
embedded templates or the user can create and save custom templates. Previously
saved ABI panels can also be imported from GeneMapper. Raw data and size
calling parameters are also user-definable and once the parameters have
been set, they can be saved and called back for future analysis.
GeneMarker HID includes an imbedded Pedigree Tool for family tree analysis. This function allows the user to easily add mates and offspring and it automatically identifies allele conflicts between parents and/or siblings. Create an original pedigree file from new data or import pre-made pedigree files (.pre, .ped, .smp).
Additional applications include relationship testing and databasing of family samples. See our Relationship Testing poster from the 2007 International Symposium on Human Identification.
Pedigree
Analysis
An expanding pedigree field accommodates and saves multiple children and mates, multiple generations and phenotype information. The pedigree files are compatible with Bennet‘s Standards for human pedigree analysis. The phenotype information and relationships are saved in files with unlimited capacity.
Family Group tool automatically draws paternity trios. Allele conflicts are linked to the electropherograms for immediate identification in paternity tests.
Kinship Analysis: Likelihood Ratios, Probabilities and Relationship Level Options
Kinship Analysis options provide flexibility to analyze data for casework and legal presentation. Options include Relationship levels, Likelihood Ratios and/or probabilities for each locus and combined values.
Select to previously analyzed projects and compare the results with GeneMarker HID's unique Project Comparison Tool. The Project Comparison Tool aligns two projects and identifies differences in peak size, height, and allele call. Additionally, if an analyst edited an allele call, the results can be immediately corroborated. The Project Comparison Tool can also be used during validation to examine the affects of certain analysis parameters on allele calling.
Select two previously analyzed projects and compare the results with GeneMarker HID's unique Project Comparison Tool. The Project Comparison Tool aligns two projects and identifies differences in peak size, height, and allele call. Additionally, if an analyst edited an allele call, the results can be immediately corroborated. The Project Comparison Tool can also be used during validation to examine the affects of certain analysis parameters on allele calling.
An Audit Trail is available when ‘Record Data Edit History’ is selected in the User Manager Settings. Any change to allele calls in the analysis will be recorded. Changes can also be recovered in the Edit History feature.
Nearly every function of GeneMarker HID has been automated
so that once the template is selected from the menu, or created by the
user, the software automatically performs the initial data analysis in
preparation for user review, thereby providing a myriad of display and
reporting options. Analysis results can be sorted and manipulated to meet
report requirements and then saved as a text file for input into LIMS
or other data base systems. CODIS files can be easily generated and exported.
In addition, GeneMarker HID will print electropherograms and peak tables
in bulk for either all or selected sample sets in a logical, easy to read
format.
Practical data analysis with the same software used in Casework and CODIS laboratories is available to instructional programs of any size.
The GeneMarkerHID instructional package includes:
One perpetual license of GeneMarker® HID software with annual update
Pre-set forensic chemistry Panels including ABI’s Identifiler® and Yfiler® kits and Promega’s PowerPlex® kits
Instruction manual
NIST dataset for casework analysis (mixed source) and anonymous single source data
Unlimited access to SoftGenetics forensic analysis technical support
120-day time-limited, fully-functional student licenses of GeneMarker® HID
The combination of the datasets and the fully functional program allow students to gain hands on experience in DNA casework analysis, without the high costs of maintaining genetic analyzers and associated laboratory equipment.
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