Multiple-Locus Variable number tandem repeat Analysis (MLVA) Analysis ...Molecular Typing of Microorganisms

MLVA (Multiple-Locus Variable number tandem repeat Analysis is a molecular typing method using VNTRs (Variable Number Tandem Repeat) similar to simple sequence repeat (SSR) and STR (Short Tandem Repeat, microsatellite) analysis in eukaryotes, and is used in research ranging from transmission route studies, antibiotic resistance (such as MRSA) to food safety (Salmonela testing) and microbial source tracking. MLVA has better resolution than other microbial identification methods (typing of capsular polysaccharides and surface protein, Spa-sequence typing), providing results that are easier to use in clustering analyses. MLVA is also less expensive and labor-intensive than multi-locus sequence typing [MLST] or pulsed-field gel electrophoresis. GeneMarker software provides fast, accurate genotyping of MLVA data from all capillary electrophoresis instruments (ABI®PRISM, Beckman-CEQ™, and MegaBACE®) and is recommended for MLVA by European Staphylococcal reference laboratories. The flexible panel editor in GeneMarker provides easy customization of panels for commercial or custom chemistries (primer sets).

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GeneMarker Applications:
MLPA® (Multiplex Ligation‐dependent Probe Amplification)
MS‐MLPA®
Trisomy Analysis
Macromolecule Analysis Tool
ARMs & Comparative Analysis (Cystic Fibrosis Analysis)
MSI (Microsatellite Instability) Analysis
Merge Project
Kinship Analysis of Wild Populations and data base
AFLP
t‐RFLP
Microsatellite (SSR, STR, VNTR)
MLVA
SBE/ SnapShot®
Cluster Analysis
TILLING® & EcoTilling with slabgel or capillary data
SNPWave®/SNPlex®
Haplotype Analysis
Loss of Heterozygosity Analysis (LOH)