ChimerMarker™ Software: STR Analysis for Chimerism Detection, Analysis and Long-term Monitoring of Engraftment

Monitoring is essential for early detection of engraftment success or disease relapse. ChimerMarker has user-friendly append functionality to add later samples to a project. The results are saved to the project and may be used to produce a longitudinal graph for visualization of any relative changes in percentage chimerism over a period of time.

This graph is an example of a projected longitudinal report for a Post-Bone Marrow Engraftment study using a single cell type, with average percentage donor chimerism monitoring over a one year period.

This example graph shows the projected post-bone marrow engraftment study.

Review Our Introductory and Double Donor Chimerism Analysis Webinars

Complete Chimerism Detection, Quantification and Analysis in one program:

• Accurate user-friendly expert system genotyping
  
• Automated Detection and Quantification of Chimerism
  
  • Single Donor Cases
    
  • Double Donor Cases
    
  • Automates repetitive calculations
• Multi-lineage Analysis and linked navigation
  
  • Concurrent Analysis of 5 tissue types per case
    
  • Saves analysis time
    
  • Decreases User Fatigue
• Options for quantification
  
  • Peak Height or Area
    
  • published algorithms
    
  • Unique algorithms for complex multiple donor cases
• User Management
  
  • Audit Trail
    
  • User Specific Access Rights
    
  • Electronic Verification in Final Reports
• Longitudinal Monitoring
• Maternal Cell Contamination (MCC)

Tools to Assist Analysts and Supervisors:

• Panel Customization for each Marker
  
  • Stutter Filters
    
  • Minimum Allele Call RFUs
    
  • Heterozygous Imbalance Flagging
    
  • Analytical and Stochastic Range Flagging
• Sizing Quality Verification/Report
  
• Project Comparison Tool
  
  • Check Concordance of Analysts
    
  • Aids with Validations
• Genetic Analyzer and Chemistry Compatibility
  
• Exportable Chimerism Analysis and LIMS Reports

Application Notes:

ChimerMarker™ Software for Automated Analysis, Chimerism Detection, Quantification
and Monitoring from Short Tandem Repeat (STR) DNA in Post-Transplant Samples App Note (PDF)